Antigen density dictates RBC clearance, but not antigen modulation, following incompatible RBC transfusion in mice
نویسندگان
چکیده
منابع مشابه
Management of RBC-transfusion dependence.
Strategies for the management of anemia in patients with myelodysplastic syndrome (MDS) have evolved following the U.S. Food and Drug Administration (FDA) approval of three new therapeutics from one of symptom amelioration with red blood cell (RBC) transfusions to one of active treatment. Most patients develop transfusion-dependent anemia over the course of their disease, however, and its adver...
متن کاملA novel role for C3 in antibody-induced red blood cell clearance and antigen modulation.
Hemolytic transfusion reactions (HTRs) due to incompatible red blood cell (RBC) transfusions are a leading cause of transfusion associated death. Although many transfused incompatible RBCs are cleared, some remain in circulation despite the presence of RBC-specific antibodies, potentially due to "antigen modulation." With a goal of better understanding incompatible RBC clearance, we generated a...
متن کاملClinical outcomes of ABO-incompatible RBC transfusions.
Factors that predict outcome after ABO-incompatible RBC transfusions are not well defined. We studied whether the volume of incompatible blood transfused would determine the signs and symptoms and survival outcome for ABO-incompatible RBC transfusions. We reviewed ABO-incompatible RBC transfusions from our institutions and our consultations for 35 years and from a survey of America's Blood Cent...
متن کاملRegulation of immune responses by RBC transfusion
It has long been appreciated that transferring allogeneic tissues between members of the same species can have complicated effects upon the recipient immune system. Transfusion represents the most common exposure to large quantities of alloantigen, which unlike solid organ transplant, occurs in the absence of pharmacological immunosuppression. Transfused products constitute a complex cellular e...
متن کاملControversies in RBC transfusion in the critically ill.
Transfusion practice has been under great scrutiny over the last 2 decades. The examination of transfusion risks and benefits have been particularly important in the critically ill patient population. This review will examine some of the important controversies still surrounding the use of RBC transfusion in the critically ill patient.
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ژورنال
عنوان ژورنال: Blood Advances
سال: 2021
ISSN: 2473-9529,2473-9537
DOI: 10.1182/bloodadvances.2020002695